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KMID : 0881720130280040360
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Journal of Food Hygiene and Safety
2013 Volume.28 No. 4 p.360 ~ p.366
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Evaluation of Macrophage Activity and Repeated Oral Dose Toxicity in Sprague-Dawley Rats on Multivitamin
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Kim Hae-Ri
Jang Hye-Yeon
Lee Hae-Nim
Park Young-Seok
Park Byung-Kwon
Kim Byeong-Soo
Kim Sang-Ki
Cho Sung-Dae
Nam Jeong-Seok
Choi Chang-Sun
Chang Soon-Hyuk
Jung Ji-Youn
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Abstract
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The objective of this study is to investigate the effect of multivitamin on macrophage activity in Raw 264.7 cell and repeated oral dose toxicity in Sprague-Dawely rat of multivitamin. Raw 264.7 cells were treated with 50 and 100 μg/mL multivitamin for 24 h. To measure the activity of macrophages, NO and TNF-α assays were performed in Raw 264.7 cells. Treatment with 50 and 100 μg/mL multivitamin for 24 h significantly increased production of NO and TNF-α compared with control groups, indicating activation of macrophages. The female rats were treated with multivitamin of control group, low group (0.24 g/kg), medium group (1 g/kg) and high group (2 g/kg) intragastrically for 4 weeks, respectively. We examined the body weight, the feed intake, the clinical signs and serum biochemical analysis. We also observed the histopathological changes of liver, ovary, brain, adrenal gland, spleen, kidney, heart and lung in rats. No significant differences in body weights, feed intake, biochemical analysis and histopathological observations between control and multivitamin treatment group were found. In conclusion, multivitamin is physiologically safe and improve macrophage activity.
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KEYWORD
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Multivitamin, Toxicity, Macrophage
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